Our work together on PEX10 and PBDs will contribute to

the fight against many other diseases!

Beyond PEX10

Peroxisomes are fantastically complex organelles involved in many critical functions throughout the body. While our work is focused on understanding the function of peroxisomes in order to help PEX10 patients and other patients of Peroxisomal Biogenesis Disorders, our efforts will help to improve our overall understanding of peroxisomes in a variety of contexts.

Current research suggests that:

» SARS-CoV-2 virus (the cause of COVID-19) directly attacks peroxisomes and peroxisome-boosting drugs have been shown to be effective against the virus in cell cultures.

» West Nile and Zika viruses use multiple mechanisms to reduce peroxisomes as a way to inhibit the production of interferon immune response.

» HIV subverts innate immune responses and causes neurocognitive dysfunction by repressing peroxisome biogenesis factors.

» Numerous neurodegenerative disorders such as Alzheimer’s and Parkinson’s disease have been linked to peroxisomal dysfunction.

» Peroxisomal dysfunction appears to contribute to the pathogenesis of a variety of diseases, including diabetes and cancer.